Gene signatures predict doxorubicin response in canine osteosarcoma

There are two chemotherapies commonly used to treat bone in : and carboplatin. Some dogs respond better to one drug than to the other. But until now, the choice has been left largely to chance. New work by members at Colorado State University Flint Animal Center presented at the (AACR) Annual Meeting 2015 demonstrates a expression model that predicts canine osteosarcoma to doxorubicin, potentially allowing veterinary oncologists to better choose which drug to use with their patients. The approach is adopted from and further validates a model known as COXEN (CO-eXpression gEne aNalysis), developed at the CU Center by center director Dan Theodorescu, MD, PhD, which is currently in clinical trials to the response of human tumors to drugs.

“This is a cool thing for us, showing that we can use human models in , and hinting that the reverse might also be true: the lessons we learn from canine osteosarcoma may help us better understand the human disease,” says Daniel L. Gustafson, PhD, CU Center investigator and director for basic research at the Flint Animal Cancer Center.

The COXEN model depends on the idea that can be defined as the sum of its genetic alterations. Rather than looking at a cancer by its site in the body — say lung cancer or or breast cancer — the COXEN model evaluates a panel of genes known to be important to the development of cancer and uses gene expression to label the cancer with a genetic signature. The model then compares the genetic signature of a cancer to the genetic of cancers for which we have treatment and outcome

… Continue reading here.
Dogs News — Sciencedaily


Sierra Price doesn’t let much on when you first meet her, but for long time friend Jett Black, that’s a different story. Sierra has a fear of something that most would consider a dream come true. Love. She consults Jett for an analyzation of a nightmare she had, and is given the synopsis that she’s in love with the one pet she knows would make her his wife, if a certain feline didn’t disapprove of it.

WARNING: This episode of LPS: Guard Dogs is a bit darker than the previous episodes that have been produced so far. Hence the PG warning in the beginning of the episode. Not all episodes of the series will be like this, however I will most likely be putting the PG warning on all future episodes as the series is not meant for very young children. Parental and viewer discretion is advised.

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Watch all episodes of Guard Dogs: https://www.youtube.com/playlist?list=PL0a0g-Xoh5LIJ-sPSyr3CTi4tvjOJ3a4I
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LPS: Something Old, Something New: https://www.youtube.com/watch?v=IbxFOPriRt0&list=UU9dZSIJLrppsVWcQq4GSkeA

LPS – Casting Call (Short): https://www.youtube.com/watch?v=Ytv2QgW4TOs

Check out some of my Littlest Pet Shop reviews: https://www.youtube.com/playlist?list=PL0a0g-Xoh5LIPNjP7V5fsMVzEZF_H2ibD

Subscribe to my channel for weekly videos! 😀
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Music by: YouTube Audio Library

Titles:
“Moth” by Silent Partner
“The Throne” by Silent Partner
“Hydra” by Huma-Huma
“Time Stops” by Silent Partner
“The Last Day” by Silent Partner
“Which Way Is Up” by Silent Partner

Arrangements by:
YouTube Audio Library
https://www.youtube.com/audiolibrary

Sound Effects by YouTube Audio Library and Mixcraft 5

ORGANIX Pate Adult Cat Food


Organix uses real pieces of fruits and vegetables for dogs, and the proprietary Carnivore Health Boost for cats. High quality proteins like chicken or turkey are the #1 ingredient in all their foods. What does that mean for your pet – complete and balanced nutrition, carefully crafted one bite at a time. Organic free-range chicken is the #1 ingredient. Certified . Food Type: Wet Food Life Stage: Adult 1-10 yrs Health Consideration: General Health Flavor: Chicken Primary Ingredient: Chicken Nutrition Option: Grain Free Package Weight: 5.5oz Ingredients: Organic Chicken, Water Sufficient for Processing, Organic Chicken Liver, Organic Turkey, Organic Pea Protein, Organic Peas, Organic Flaxseed, Organic Carrots, Organic Alfalfa, Calcium Carbonate, Dextrose, Glycine, Sodium Phosphate, Salt, Potassium Chloride, Taurine, Minerals (Iron Amino Acid Chelate, Zinc Amino Acid Chelate, Cobalt Amino Acid Chelate, Copper Amino Acid Chelate, Manganese Amino Acid Chelate, Sodium Selenite, Potassium Iodide), Vitamins (Vitamin E Supplement, Vitamin A Supplement, Vitamin D3 Supplement, Vitamin B12 Supplement, Thiamine Mononitrate, Niacin, D-Calcium Pantothenate, Pyridoxine Hydrochloride, Riboflavin Supplement, Folic Acid, Biotin),Organic Cranberries, Yucca Schidigera Extract, Choline Chloride Guaranteed Analysis: Crude Protein (min) 9.50% Crude Fat (min) 5.00% Crude Fiber (max) 1.00% Moisture (max) 78.00% Ash (max) 2.10% Taurine (min) 0.10%

Price: $ 1.67
Sold by PetSmart


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Comments

    • MusicalLPS ™
    • April 29, 2015

    Whoa Little! This was such an interesting episode! I was on the edge of my
    seat when she wanted to put herself on the threat list. Amazing job.

    • Rileigh Dunn
    • April 29, 2015

    Oooh! Can’t wait until the next episode!

    • Roe Durando
    • April 29, 2015

    When I heard “Latin black” sorry if I spelled it wrong but when I heard
    jetts mom died I felt like I was gonna cry xD

    • MyBeautifulMuffins
    • April 29, 2015

    I’m dying of both suspense and sadness!
    How do you make the robot voices?

    • Stargirl107 .
    • April 28, 2015

    Why????!?!?!? Why would her mom want to add her name to the list!!?!?!?! 

    • Bri Films
    • April 28, 2015

    Wait what??? She put herself on the threat list to kill herself??!? :(

    • LPSFluffy
    • April 28, 2015

    Another awesome episode Maddie! :)

    • VannerSnow SMV
    • April 28, 2015

    I can’t believe his mom did that, was she that ashamed to be Jet’s mom? You
    do a really good job. I’m hooked all the way through. There isn’t a part
    where I get bored. This is better than LPS Popular by far I think :)

    • Nariah Carswell
    • April 28, 2015

    can you make 6# already cause i love it

    • LPSKendall475
    • April 28, 2015

    I believe Jett’s mom made Jessa kill her so she would not longer have to
    suffer the pain she internally felt with Jett. Or, She felt as if she
    wasn’t worth Jett’s love. For she had never said she loved him. But why is
    Sierra a suspect? And earlier in the show Jett said He wanted to hear her
    say “I love you.” before she was gone, Like dead.

    • HYWM Productions
    • April 28, 2015

    I don’t understand!!! WHY DID SHE KILL HERSELF IS IT BECAUSE SHE THOUGHT
    SHE WASNT GOOD ENOUGH FOR HER SON?!?!?!

    • Summer DuBois
    • April 28, 2015

    Whoa whoa whoa…..WHAT THE?!? U CANT END LIKE THAT NOO!!!! Did jetts mom
    kill herself and enter Sierra into the threat list or enter herself into
    the threat list so Jenna would kill her?, if she enters herself then why
    would sierra be a questionable suspect?!?!

    • IzzyLPS
    • April 28, 2015

    W-WHAT THE WHAT. Why…Why…
    Another amazing episode LPSLittleProductions! Keep it up! <3 :D

    • LPSLittleProductions
    • April 28, 2015

    Welcome to the fifth episode of LPS: Guard Dogs, hope you enjoy! :D

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