There are two chemotherapies commonly used to treat bone cancer in dogs: doxorubicin and carboplatin. Some dogs respond better to one drug than to the other. But until now, the choice has been left largely to chance. New work by University of Colorado Cancer Center members at Colorado State University Flint Animal Cancer Center presented at the American Association for Cancer Research (AACR) Annual Meeting 2015 demonstrates a gene expression model that predicts canine osteosarcoma response to doxorubicin, potentially allowing veterinary oncologists to better choose which drug to use with their patients. The approach is adopted from and further validates a model known as COXEN (CO-eXpression gEne aNalysis), developed at the CU Cancer Center by center director Dan Theodorescu, MD, PhD, which is currently in clinical trials to predict the response of human tumors to drugs.
“This is a cool thing for us, showing that we can use human models in canine cancer, and hinting that the reverse might also be true: the lessons we learn from canine osteosarcoma may help us better understand the human disease,” says Daniel L. Gustafson, PhD, CU Cancer Center investigator and director for basic research at the Flint Animal Cancer Center.
The COXEN model depends on the idea that cancer can be defined as the sum of its genetic alterations. Rather than looking at a cancer by its site in the body — say lung cancer or prostate cancer or breast cancer — the COXEN model evaluates a panel of genes known to be important to the development of cancer and uses gene expression to label the cancer with a genetic signature. The model then compares the genetic signature of a cancer to the genetic signatures of cancers for which we have treatment and outcome
Sierra Price doesn’t let much on when you first meet her, but for long time friend Jett Black, that’s a different story. Sierra has a fear of something that most would consider a dream come true. Love. She consults Jett for an analyzation of a nightmare she had, and is given the synopsis that she’s in love with the one pet she knows would make her his wife, if a certain feline didn’t disapprove of it.
WARNING: This episode of LPS: Guard Dogs is a bit darker than the previous episodes that have been produced so far. Hence the PG warning in the beginning of the episode. Not all episodes of the series will be like this, however I will most likely be putting the PG warning on all future episodes as the series is not meant for very young children. Parental and viewer discretion is advised.
Watch all episodes of Guard Dogs: https://www.youtube.com/playlist?list=PL0a0g-Xoh5LIJ-sPSyr3CTi4tvjOJ3a4I
LPS: Something Old, Something New: https://www.youtube.com/watch?v=IbxFOPriRt0&list=UU9dZSIJLrppsVWcQq4GSkeA
LPS – Casting Call (Short): https://www.youtube.com/watch?v=Ytv2QgW4TOs
Check out some of my Littlest Pet Shop reviews: https://www.youtube.com/playlist?list=PL0a0g-Xoh5LIPNjP7V5fsMVzEZF_H2ibD
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Music by: YouTube Audio Library
“Moth” by Silent Partner
“The Throne” by Silent Partner
“Hydra” by Huma-Huma
“Time Stops” by Silent Partner
“The Last Day” by Silent Partner
“Which Way Is Up” by Silent Partner
YouTube Audio Library
Sound Effects by YouTube Audio Library and Mixcraft 5
Organix uses real pieces of fruits and vegetables for dogs, and the proprietary Carnivore Health Boost for cats. High quality proteins like chicken or turkey are the #1 ingredient in all their foods. What does that mean for your pet – complete and balanced nutrition, carefully crafted one bite at a time. Organic free-range chicken is the #1 ingredient. Certified USDA Organic. Food Type: Wet Food Life Stage: Adult 1-10 yrs Health Consideration: General Health Flavor: Chicken Primary Ingredient: Chicken Nutrition Option: Grain Free Package Weight: 5.5oz Ingredients: Organic Chicken, Water Sufficient for Processing, Organic Chicken Liver, Organic Turkey, Organic Pea Protein, Organic Peas, Organic Flaxseed, Organic Carrots, Organic Alfalfa, Calcium Carbonate, Dextrose, Glycine, Sodium Phosphate, Salt, Potassium Chloride, Taurine, Minerals (Iron Amino Acid Chelate, Zinc Amino Acid Chelate, Cobalt Amino Acid Chelate, Copper Amino Acid Chelate, Manganese Amino Acid Chelate, Sodium Selenite, Potassium Iodide), Vitamins (Vitamin E Supplement, Vitamin A Supplement, Vitamin D3 Supplement, Vitamin B12 Supplement, Thiamine Mononitrate, Niacin, D-Calcium Pantothenate, Pyridoxine Hydrochloride, Riboflavin Supplement, Folic Acid, Biotin),Organic Cranberries, Yucca Schidigera Extract, Choline Chloride Guaranteed Analysis: Crude Protein (min) 9.50% Crude Fat (min) 5.00% Crude Fiber (max) 1.00% Moisture (max) 78.00% Ash (max) 2.10% Taurine (min) 0.10%
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1. Kong Wobbler A lot of dog owners have reported positive results using a Kong Wobbler. The toy is designed to be filled with dog treats or kibble. The design makes it virtually impossible for your dog to get the treats out of the toy, which can help prevent separation anxiety. It takes a little […]
Relocating to a new house is a whole lot of work, especially when you are doing it all by yourself. This includes going through an adjustment period, where you will feel the need to adapt to the new environment and other factors. Just like humans, our furry friends also need to have some time to […]
Welcoming a pet into your home as a friend for a lifetime Is always a dreamy milestone to achieve. But if you are someone who starts to show allergic reactions as soon as you come in contact with the pet, then this dreamy situation can turn into a Nightmare. So, if you are facing this […]
Recent estimates indicate that approximately 90 million dogs – and close to 100 million cats – have a home in the United States. When it comes to their pets, animal lovers spare no expense in caring for their pet or showcasing their love for man’s best friends. But don’t let that last statement fool you […]