There are two chemotherapies commonly used to treat bone cancer in dogs: doxorubicin and carboplatin. Some dogs respond better to one drug than to the other. But until now, the choice has been left largely to chance. New work by University of Colorado Cancer Center members at Colorado State University Flint Animal Cancer Center presented at the American Association for Cancer Research (AACR) Annual Meeting 2015 demonstrates a gene expression model that predicts canine osteosarcoma response to doxorubicin, potentially allowing veterinary oncologists to better choose which drug to use with their patients. The approach is adopted from and further validates a model known as COXEN (CO-eXpression gEne aNalysis), developed at the CU Cancer Center by center director Dan Theodorescu, MD, PhD, which is currently in clinical trials to predict the response of human tumors to drugs.
“This is a cool thing for us, showing that we can use human models in canine cancer, and hinting that the reverse might also be true: the lessons we learn from canine osteosarcoma may help us better understand the human disease,” says Daniel L. Gustafson, PhD, CU Cancer Center investigator and director for basic research at the Flint Animal Cancer Center.
The COXEN model depends on the idea that cancer can be defined as the sum of its genetic alterations. Rather than looking at a cancer by its site in the body — say lung cancer or prostate cancer or breast cancer — the COXEN model evaluates a panel of genes known to be important to the development of cancer and uses gene expression to label the cancer with a genetic signature. The model then compares the genetic signature of a cancer to the genetic signatures of cancers for which we have treatment and outcome
Sierra Price doesn’t let much on when you first meet her, but for long time friend Jett Black, that’s a different story. Sierra has a fear of something that most would consider a dream come true. Love. She consults Jett for an analyzation of a nightmare she had, and is given the synopsis that she’s in love with the one pet she knows would make her his wife, if a certain feline didn’t disapprove of it.
WARNING: This episode of LPS: Guard Dogs is a bit darker than the previous episodes that have been produced so far. Hence the PG warning in the beginning of the episode. Not all episodes of the series will be like this, however I will most likely be putting the PG warning on all future episodes as the series is not meant for very young children. Parental and viewer discretion is advised.
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