Possible biological trigger for canine bone cancer found

Researchers at the University of Wisconsin-Madison School of Veterinary Medicine (SVM) have identified the mechanism that may give some cells the ability to form tumors in .

The recent study uncovered an association between the increased expression of a particular gene in and more aggressive behavior in a form of . It may also have implications for human cancers by detailing a new pathway for tumor formation.

The findings, published online this month in the journal Veterinary and Comparative Oncology, may eventually provide oncologists with another target for therapy and improve outcomes for patients with the disease.

The researchers examined generated from dogs with osteosarcoma, a common bone that also affects people, with the intent of uncovering why only some cells generate tumors. After the dogs underwent tumor-removal surgery at UW Veterinary Care — the SVM’s veterinary medical teaching hospital — cells from the tumors were grown in the lab.

This led to six different cell lines, which were then transplanted into mice. The researchers then looked to see which lines developed tumors and which did not and studied the differences between them.

“We several hundred genes that expressed differently between the tumor-forming and nontumor-forming cell lines,” says Timothy Stein, an assistant professor of oncology. However, one protein called frizzled-6 was present at levels eight times higher in cells that formed tumors.

In the complicated process of , the genetic information encoded within DNA is eventually converted into RNA and proteins, which are responsible for a variety of vital cellular functions. Frizzled-6 plays a key role in relaying signals from the outside to the inside of a

… Continue reading here.
Dogs News — Sciencedaily


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    • Trish
    • March 25, 2015
    10 of 10 people found the following review helpful
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    Dog loves these, December 27, 2013
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    Trish

    Verified Purchase(What’s this?)
    Feed one of these to my dog after her every meal (of dry dog food) and she has never had dental problems, her breath actually smells wonderfully fresh, and she’s never had to have her teeth professionally cleaned. In fact she’s 13 and her vet still marvels at what great shaped her teeth are in. No plaque or bad breath from my elderly pooch.

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    • carelcarel "in CA"
    • March 25, 2015
    13 of 13 people found the following review helpful
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    Great product, but they are many dollars cheaper, elsewhere., August 9, 2013
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    My dog loves these…however….I will be purchasing them from WalMart, from now on, as they are only $15.98, for exactly the same product & amount.

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    • Kenneth Howe
    • March 25, 2015
    25 of 26 people found the following review helpful
    5.0 out of 5 stars
    Work great and much cheaper!, December 22, 2012
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    This review is from: Pedigree Dentastix Fresh Oral Care Treats for Dogs, Large, 1.52-Pound (Misc.)
    After we first got our dog we were told that it’s important to use Greenies every day to keep his dental health well. However, the cost is outrageous when used on a daily basis so I researched a lesser expensive product that would get the same results and I definitely found it with these Pedigree Dentastix. My dog loves them, has one every day and his teeth are sparkling white.

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