Osteosarcoma immunotherapy study has potential to benefit both dogs, humans

is a highly aggressive bone tumor that affects at least 10,000 annually in the United States. It is most commonly seen in the adult large and giant breeds such as Rottweilers, Labrador retrievers, greyhounds, Newfoundlands, Irish wolfhounds, Great Danes and Scottish deerhounds.

It is estimated that 90-95 percent of subjects have microscopic (spread of to other parts of the body at the time of diagnosis). Standard of care includes removal of the primary tumor—usually by —followed by . given after amputation delays the development of metastatic disease; however, despite treatment, most dogs die of the disease within one year of diagnosis.

A new option may be available in the future if Dr. ’s research at the produces satisfactory results. , an assistant professor of medicine and a Board-certified ACVIM Diplomate in Small Animal Internal Medicine, is evaluating the first vaccine for and will provide attendees at the 2014 ACVIM Forum an update on that work in the presentation “Osteosarcoma Vaccine Research” at 4:25 p.m. Thursday, June 5 at the Gaylord Opryland Resort & Convention Center in Nashville.

The approach harnesses the power of the dog’s immune system, “training” it to seek out and destroy cancer cells that remain after amputation and chemotherapy.

Over a century ago, an orthopedic surgeon named William Coley recognized that human with concurrent bacterial infections that caused high fevers had improved overall survival times compared to those sarcoma patients without infection. This led him to develop a therapeutic concoction of live bacteria that he injected into patients with bone sarcomas. He documented improved survival and in some cases, complete remission in individuals with the aggressive disease by using this early form of “immune therapy.”

Mason’s team is employing similar immune therapeutic strategy to treat dogs with osteosarcoma that have undergone the standard of care treatment (amputation and chemotherapy) to prevent metastatic disease. “The concept is that administration of the Listeria-based (genetically modified bacteria) vaccine will activate the patient’s immune system and educate it to recognize cells that express the target molecule,” says Mason.

Dogs are given the live bacterial vaccine intravenously, Mason explains, and it induces a mild transient fever on the day of vaccination. The dogs are usually treated as outpatients and return home the same day. “We have found highly encouraging results when the vaccine is given to patients that have no evidence of metastatic disease at the time of the enrollment, which is three weeks after the last chemotherapy is administered. Four out of the first five dogs vaccinated are alive at least two years after their initial diagnosis, which is more than twice their expected survival duration. The vaccine has not yet shown any serious short- or long-term side effects, either.”

Mason says the results have

… Continue reading here.
Dogs News — Sciencedaily

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    • Justine A. Lee "Dr. Justine Lee"
    • May 26, 2014
    22 of 25 people found the following review helpful
    5.0 out of 5 stars
    Veterinary approved…, August 26, 2010
    By 
    Justine A. Lee “Dr. Justine Lee” (Saint Paul, MN United States) –
    (REAL NAME)
      

    As a veterinarian, I’ve dispensed a lot of medications for both dogs and cats…that is, until I had to start medicating my own pets. I’ve became a lot more empathetic now that I’ve realized that I can barely pill my own cat (who runs away from me), and that my dog will not take pills in cheese or peanut butter. In fact, pilling my own pets has smartened me up on what meds pets really need. As a result, I’ve started prioritizing pills – in other words, I rank the order of importance of each prescription for pet owners, so they know which pills are an absolute MUST give, and which ones they can skip if they are getting desperately fed up with pilling.

    Since then, my life has changed… thanks to Pill Pockets. I regret not inventing these, as it was one of those “duh” products that came out, making you wish you had the money-making patent. Whoever owns a dog that needs to be pilled chronically, pay heed. The Greenies Pill Pockets are awesome… that is, for dogs, at least.
    My dog recently got put on a bunch of medications, and he’s super picky (although less so, since getting put on steroids!). Being that he needs a total of 5 medications a day, I found Pill Pockets to be a true life saver, as they improve both my dog’s and my quality of life. These little tasty, greasy, soft, malleable pockets are designed so that you can stick the pill (or multiple pills) in the center, and seal them into a hidden ball of “treat.” It’s like playing with palatable play-dough. Drop it in the food, and voila, it “makes pills a treat to give!”

    The pros: Pill Pockets are easy, convenient, tasty, and come in multiple flavors (Dog: beef and chicken; Cat: salmon and chicken. It also comes in a hypoallergenic flavor – duck and pea – for both species with food allergies). More importantly, they are palatable – dogs seem to love them. Another pro is that they come in multiple sizes, and I’m able to stuff 5 pills – yes all 5 pills – into the larger “capsule” dog Pill Pockets.

    The cons: One of my two cats won’t touch Pill Pockets. This is, of course, the cat who actually needs to take medication. He also won’t touch Feline Heartgard monthly chewable pills either, so I suspect he doesn’t like moist treats. So, try at your own risk, particularly if you have a finicky cat. The other con is that Pill Pockets are a bit greasy – they have a high vegetable oil content. As ingredients are listed in order of use, vegetable oil is #4 for the dog pill pockets. While this doesn’t affect the health of your pet, a hand-washing is a MUST after playing with Pill Pockets (which you should always do when handling your pet’s meds, anyway). That said, I know that the vegetable oil is needed to keep the Pill Pockets malleable (easy to fold and maneuver). The other con – cost. They’re not cheap, and if your pet is on loads of meds, it can certainly add up. Try jamming 5 pills in one capsule to help. But anything for Fido, right?!

    Dr. Justine Lee, DVM, DACVECC
    Author of “It’s a Dog’s Life… but It’s Your Carpet” and “It’s a Cat’s World… You Just Live In It”
    […].

    0

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    • Jonathan Sabin
    • May 26, 2014
    42 of 46 people found the following review helpful
    5.0 out of 5 stars
    The 28th Five Star Review, July 10, 2010
    By 
    Jonathan Sabin (Ellenton, FL USA) –
    (VINE VOICE)
      
    (REAL NAME)
      

    Verified Purchase(What’s this?)
    Rarely have I encountered a product that doesn’t have at least ONE person who either thinks it’s junk, or gives a (bogus) low review because the delivery guy accidentally dropped the package before leaving the item at the door.

    As of this moment, 100% of the people reviewing the Greenies PILL POCKETS have given them a five-star rating, and I’m enthusiastically joining the crowd!

    If you’re a dog owner, you’ve almost certainly had to, at some point, give your dog a pill that he or she was reluctant to take. The usual remedy until now, (as suggested by our vet) was to simply shove the thing down the poor dog’s throat, and then rub their neck to help the pill go down.

    Recently, one of our dogs –a large yellow lab named Chip– was suffering from untreatable throat cancer, but he still needed to take a number of pills to make his final days a little more comfortable. The vet specifically mentioned AVOIDING the “shove and rub” technique as it would be very painful for the dog –who at that point was even reluctant to eat his regular food.

    Someone mentioned PILL POCKETS. We picked up a bag and lo and behold, they worked like a champ. Though Chip was still not really interested in eating a meal, the *very* meaty smell of the PILL POCKETS was irresistible to him, and he happily gobbled up his meds.

    Sadly, we lost Chip about a week later, but then our other dog developed a minor skin rash that required he take some antibiotics. Eubie is a Border Collie, and they tend to figure things out before you do –and we were astounded when he wolfed down his medicine and then looked at us as if to ask “is that all –when do I get another?!”

    My technique for using the PILL POCKETS is to stuff the pill(s) inside, pinch off the open end –and then, using my palms, “roll” the pocket into a smooth, round ball. With Eubie at least, he loves the smell so much, that he simply swallows it whole.

    In fact, I discovered another great use for the PILL POCKETS and that is to take a rawhide bone and smear the nooks and crannies with a single pill pocket. Since they’re kind of “doughy” in texture, they’re perfect in this regard –and for a dog that will happily walk around the house with the rawhide bone for days without ever chewing on it, we’ve found that the “pill pocket infused” rawhide is something that he HAS to chew on. (In fact, he was SO focused on this task, that for the first time ever, he actually ignored the fireworks on July 4th…. it was truly amazing!)

    – Jonathan Sabin

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    • SweetCheezus
    • May 26, 2014

    Full walkthrough of this game on my chan if interested! :D

    • TheKSH991
    • May 26, 2014

    How did u get it early on pc, steam usually doesnt open the game up to
    people until the release date or did you just buy a box copy 

    • Jo Decraser
    • May 26, 2014

    Xbox Not PC…

    • Jeebus Crust
    • May 26, 2014

    The graphics honestly don’t look that bad, why’s everyone bitching over it?
    This game looks like it has more than just, go to this place shoot these
    bad guys or deliver this package from point A to point B.

    • LG tovar
    • May 26, 2014

    Yay more ps4 footage 

    • Whaleping Davis
    • May 26, 2014

    First!!

    • Okey Agu
    • May 26, 2014

    Upgrade your skills

    • Tu_Ta_Te
    • May 26, 2014

    It looks like ps4…

    • W LCALLSTAR
    • May 26, 2014

    hey guys great game want a chance of winning it join
    http://www.twitch.tv/WLCALLSTAR for PS4/XONE

    • LG tovar
    • May 26, 2014

    Yay more ps4 footage 

    • dinocujko
    • May 26, 2014

    this looks boring…

    • Connor Kenway
    • May 26, 2014

    Game looks like so much fun!

    • Liam Guček-Pagon
    • May 26, 2014

    how long is the game????

    • thetalented nostradamus
    • May 26, 2014

    It gets boring……

    • Sebatian Flute
    • May 25, 2014

    upload fasteeeeer!!! ^^

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