Supercomputer Beagle can analyze 240 whole genomes in two days

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Researchers say it would take a single 2.1 GHz CPU roughly 47 years to do what the completed in 50 hours.

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The time and cost of entire human has dropped dramatically in the 21st century. Unfortunately, it can take months to analyze the results, given that there are 3.2 billion base pairs to decode. (As such, it’s become popular instead to focus on the fewer than 2 percent of the genome that codes for proteins, in a process called exome sequencing.)

Now researchers out of the University of Chicago are reporting in the journal Bioinformatics that one of the world’s fastest supercomputers devoted to life sciences can analyze 240 full genomes in 50 hours. They estimate that the same task would have taken a single 2.1 GHz CPU more than 47 years.

To be clear, tapping the extraordinary powers of the Beagle (named after the ship that carried then 22-year-old on his scientific voyage around the world in 1831) isn’t going to keep the cost of genome analysis down, which is of course an imperative if the tech is to be clinically useful. It does, however, demonstrate that genome analysis has the potential to be far, far faster than it is today.

“The can process many simultaneously rather than one at a time,” first author Megan Puckelwartz, a postdoctoral fellow at the University of Chicago, said in a school news release. “It converts , which has primarily been used as a research tool, into something that is immediately valuable for patient care.”

The researchers report that they used one quarter of the Beagle’s operating capacity in conjunction with commercially available software packages to analyze raw sequencing data from 61 human , and that using approach not only improved speed dramatically but also accuracy. will presumably help reduce the cost of both sequencing and analyzing whole down the road.

In fact, study author Elizabeth McNally, director of the Cardiovascular Genetics clinic at the University of Chicago Medicine, said in the news release that if the cost of analysis can be moved into the $ 1,000 range, which is the current target on the sequencing side, it will make sense to analyze entire instead of just a small fraction of them.

Because can help spot an estimated 85 percent

… Continue reading here.
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